Project 3 – Dr. Jefferson Kinney

The Role of GABA in Microglial Activation and Neurodegeneration in Alzheimer's Disease

Jefferson Kinney, PhD

Jefferson W. Kinney, PhD

Specific Aims:

  1. Examination of GABA and immune alterations in a mouse model of AD.
              
  2. Cross CX3CR1-CRE-ER mice with GABAB(1)lox511/lox511 mice to allow an inducible knockout of GABAB receptors specific to microglia.
              
  3. Determine if removal of GABABR on microglia exacerbate behavioral or pathological markers of AD in each of the groups tested in SA2 (WT, 3xTg-AD, GABABR microglial KO, 3xTg-AD + GABABR microglial KO).

Internal Mentor

Martin Schiller, PhD

Martin Schiller, PhD
Professor at UNLV

       

External Mentor

Jeffrey L. Cummings, MD, ScD
Jeffrey L. Cummings, MD, ScD
Associate director of the Center for Neurodegeneration and Translational Neuroscience