Project 3 – Dr. Jefferson Kinney

The Role of GABA in Microglial Activation and Neurodegeneration in Alzheimer's Disease

Jefferson W. Kinney, PhD

Specific Aims:

  1. Examination of GABA and immune alterations in a mouse model of AD.
              
  2. Cross CX3CR1-CRE-ER mice with GABAB(1)lox511/lox511 mice to allow an inducible knockout of GABAB receptors specific to microglia.
              
  3. Determine if removal of GABABR on microglia exacerbate behavioral or pathological markers of AD in each of the groups tested in SA2 (WT, 3xTg-AD, GABABR microglial KO, 3xTg-AD + GABABR microglial KO).

Internal Mentor

Martin Schiller, PhD
Professor at UNLV