Project 3 – Dr. Jefferson Kinney
The Role of GABA in Microglial Activation and Neurodegeneration in Alzheimer's Disease
![Jefferson Kinney, PhD Jefferson Kinney, PhD](https://i0.wp.com/nevadacntn.org/wp-content/uploads/2023/02/Jefferson_Kinney.png?resize=240%2C300&ssl=1)
Jefferson W. Kinney, PhD
Specific Aims:
- Examination of GABA and immune alterations in a mouse model of AD.
- Cross CX3CR1-CRE-ER mice with GABAB(1)lox511/lox511 mice to allow an inducible knockout of GABAB receptors specific to microglia.
- Determine if removal of GABABR on microglia exacerbate behavioral or pathological markers of AD in each of the groups tested in SA2 (WT, 3xTg-AD, GABABR microglial KO, 3xTg-AD + GABABR microglial KO).
Internal Mentor
![](https://i0.wp.com/nevadacntn.org/wp-content/uploads/2017/12/image002.jpg?resize=604%2C708&ssl=1)
Martin Schiller, PhD
Professor at UNLV