Amanda Leisgang – GABA specific changes in a mouse model of Alzheimer’s disease

     Alzheimer’s disease (AD) is a progressive neurodegenerative disorder associated with learning and memory deficits, neuronal loss, and eventually death. AD is characterized by the appearance of two key pathological features. These include the accumulation of...

Discrepancy in freezing of gait measurements: self-report, clinical, and physical therapy assessments

Brent Bluett1, Ece Bayram1, Jason Longhurst1, Sarah J. Banks1, Irene Litvan2 1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA. 2University of California San Diego Department of Neurosciences, Parkinson and Other Movement Disorders Center, La...

Effect of levodopa on fronto-parietal network connectivity in freezing of gait in Parkinson’s disease

Karthik Sreenivasan1, Ece Bayram1, Sarah J. Banks1, Xiaowei Zhuang1, Virendra Mishra1, Zhengshi Yang1, Christopher Bird1, Dietmar Cordes1, Irene Litvan2, Brent Bluett1 1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA, 2University of California...

The Relationship Between Inhibitory Control and Freezing of Gait in Parkinson’s Disease

Ece Bayram1, Sarah J. Banks1, Jason Longhurst1, Brent Bluett1 1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA. Background and Objective: Neural correlates of freezing of gait in Parkinson’s disease (PD-FOG) consist of the locomotor network,...

The Effect of Levodopa on Dual-Tasking in Parkinson’s Disease Freezing of Gait

Ece Bayram1, Jason Longhurst1, Sarah J. Banks1, Zoltan Mari1, Brent Bluett1 1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA. Background and Objective: Starting to walk, turning, narrow spaces, and dual-tasking increase the frequency and severity...

Effects of hyperglycemia in the APP/PS1 mouse model of Alzheimer’s disease

Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder that is characterized by memory deficits, neuronal loss, and death. Pathological hallmarks of the disorder include the accumulation of amyloid beta (Ab) plaques and neurofibrillary tangles composed...

Assessing Collaborative Interactions within a COBRE Funded Research Center

Gwen C. Marchanda, Kristine M. Bragga & Jonathan C. Hilpertb aUniversity of Nevada, Las Vegas bGeorgia Southern University Background and Objective Effective assessment of multidisciplinary collaborative research efforts requires strategies to determine how well...

Novel diffusion-derived biomarkers in Parkinson’s disease with and without freezing of gait

Virendra Mishra1, Ece Bayram1, Karthik Sreenivasan1, Xiaowei Zhuang1, Zhengshi Yang1, Christopher Bird1, Irene Litvan2, Sarah J Banks1, Dietmar Cordes1, Brent Bluett1 Background and Objective: Diffusion magnetic resonance imaging analysis (dMRI) using a bi-tensor...

Cortico-striatal-brainstem structural connectivity patterns in in Parkinson’s disease with and without freezing of gait

Virendra Mishra1, Ece Bayram1, Karthik Sreenivasan1, Xiaowei Zhuang1, Zhengshi Yang1, Christopher Bird1, Irene Litvan2, Sarah J Banks1, Dietmar Cordes1, Brent Bluett1 Background and Objective: Freezing of gait in Parkinson’s disease (PD) is a poorly understood...

A Novel Approach to Recruitment for Alzheimer’s Disease Research Studies: The Experience of the Center for Neurodegeneration and Translational Neuroscience (CNTN)

Aaron Ritter, Kat Hartley-Mack, Marlen Ibarra, Kirsten Calvin, Jeffrey Cummings Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas Nevada Background: Recruitment for Alzheimer’s disease (AD) research studies is challenging. With estimates suggesting that...

The Clinical Core of the Center for Neurodegeneration and Translational Research: A Novel Approach to the Study of Alzheimer’s and Parkinson’s Disease

Aaron Ritter, Kirsten Calvin, Marlen Ibarra Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas Nevada Background and Objective: The Center for Neurodegeneration and Translational Research (CNTN) represents a novel approach to studying Alzheimer’s and...

Personalized Medicine in Nevada Center of Biomedical Research Excellence

Martin R. Schiller, Nora Caberoy, JIngchun Chen, Xianging Chen, Mira Han, Joseph Lombardo, Michael Nasiak, Edwin Oh, Shirley Shen, Qing Wu, and Xiaogang Wu Our COBRE program in the 2018 cohort is building a sustained interdisciplinary center in personalized medicine....